>After you have downloaded the zip file use an unzip program it will unzip to a folder.You then run the program by double left click mouse button on the Metaseq.exe and follow the instructions.

Please mind your language it is offensive and not called for.

Anybody cannot answer your trouble because you didn't write which version of Windows you use, what browser you use for download, what you did, what happened and what message was displayed.
Please give a detailed explanation.